Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und Molekulare Biowissenschaften

Ebert, Antje, PD Dr.

Research group leader at the Department of Cardiology and Pneumology


  • 2000 - 2006 Diploma in Biology, studies at the Universities of Mainz and Heidelberg, Cardiff University of Wales/UK, Johns Hopkins University MD/USA
  • 2006 - 2010 PhD at Heidelberg University, Biochemistry Center (Graduate Research College 1188)
  • 2010 - 2015 Postdoctoral fellow at Stanford University School of Medicine, Cardiovascular Institute (DFG fellowship); Department of Chemical and Systems Biology (Associated member)
  • 2015 - 2016 Instructor at Stanford University School of Medicine, Cardiovascular Institute; Department of Chemical and Systems Biology (Associated member)
  • since 2016 Research group leader at the University Medical Center Göttingen, Department of Cardiology and Pneumology
  • 2021 Habilitation in Molecular Biology and Biochemistry



Major Research Interests

Molecular interactions and signaling in cardiomyopathy

Our group studies the cell biology of cardiovascular diseases. We utilize human model systems such as induced pluripotent stem cells (iPSCs) in combination with site-specific genome editing, as well as biochemical, biophysical, and systems medicine approaches. With these interdisciplinary tools, we investigate the molecular functions of cardiac diseases, such as dilated and hypertrophic cardiomyopathy (DCM/HCM) as well as cardiac ischemia, leading causes of heart failure world-wide. We are focusing on molecular and biophysical signaling circuits that regulate intracellular transport processes, organelle function, and homeostasis in cardiomyocytes, endothelial cells, and other cells of the cardiac vasculature as well as their interfaces with the immune and neuronal systems. Our goals are to characterize and rescue molecular patho-phenotypes in human 2D/3D models of iPSC-derived cells, in live primary cell types of the heart as well as in cardiac tissues derived from adult patients. Ultimately, we aim to contribute novel therapeutic and regenerative directions for cardiac disease.


Homepage Department/Research Group

https://herzzentrum.umg.eu/cardiovascular-cell-biology-and-systems-medicine//index.html

http://www.ebert-lab.com/groupmembers.html


Selected Recent Publications



  • Dai Y, Ignatyeva N, Xu H, Wali R, K, Brandenburg S, Lenz C, Pronto J, Fakuade FE, Sossalla S, Zeisberg EM, Janshoff A, Kutschka I, Voigt N, Urlaub H, Rasmussen TB, Mogensen J, Lehnart SE, Hasenfuss G, Ebert AD. An alternative mechanism of subcellular iron uptake deficiency in cardiomyocytes. Circ Res. 2023 Jul 7;133(2):e19-e46. doi: 10.1161/CIRCRESAHA.122.321157.

  • Xu H, Wali R, Cheruiyot C, Bodenschatz J, Hasenfuss G, Janshoff A, Habeck M, Ebert AD Non-negative blind deconvolution for signal processing in a CRISPR-edited iPSC-cardiomyocyte model of dilated cardiomyopathy. FEBS Lett. 2021 Sep 5. doi: 10.1002/1873-3468.14189.

  • Malkovskiy AV, Ignatyeva N, Dai Y, Hasenfuss G, Rajadas J, Ebert AD. Integrated Ca2+ flux and AFM force analysis in human iPSC-derived cardiomyocytes. Biol Chem. 2020 Oct 27;402(1):113-121. doi: 10.1515/hsz-2020-0212.

  • Dai Y, Amenov A, Ignatyeva N, Koschinski A, Xu H, Soong P, Tiburcy M, Linke W, Zaccolo M, Hasenfuss G, Zimmermann W, Ebert AD. Troponin Destabilization Impairs Sarcomere-Cytoskeleton Interactions in DCM Patient-Specific iPSC-Cardiomyocytes. Sci Rep. 2020 Jan 14;10(1):209. doi: 10.1038/s41598-019-56597-3.

  • Kodo K, Ong SG, Jahanbani F, Termglinchan V, Hirono K, InanlooRahatloo K, Ebert AD, Shukla P, Abilez OJ, Churko JM, Karakikes I, Jung G, Ichida F, Wu SM, Snyder MP, Bernstein D, Wu JC (2016) iPSC-derived cardiomyocytes reveal abnormal TGF-β signalling in left ventricular non-compaction cardiomyopathy. Nat Cell Biol. 2016 Oct;18(10):1031-42

  • Riegler J, Tiburcy M, Ebert AD, Tzatzalos E, Raaz U, Abilez OJ, Shen Q, Kooreman NG, Neofytou E, Chen V, Wang M, Meyer T, Tsao PS, Connolly AJ, Couture LA, Gold JD, Zimmermann WH, Wu JC (2015) Human Engineered Heart Muscles Engraft and Survive Long-Term in a Rodent Myocardial Infarction Model. Circ Res. 2015 Aug 19

  • Ebert AD, Kodo K, Liang P, Wu H, Huber BC, Riegler J, Churko J, Lee J, de Almeida P, Lan F, Diecke S, Burridge PW, Gold JD, Mochly-Rosen D, Wu JC (2014) Characterization of the molecular mechanisms underlying increased ischemic damage in the aldehyde dehydrogenase 2 genetic polymorphism using a human induced pluripotent stem cell model system. Sci Transl Med. 2014 Sep 24;6(255):255ra130

  • Sanchez-Freire V, Ebert AD, Kalisky T, Quake SR, Wu JC (2012) Microfluidic single-cell real-time PCR for comparative analysis of gene expression patterns. Nature Protocols 2012 Apr 5;7(5):829-38

  • Ebert AD, Laussmann M, Wegehingel S, Kaderali L, Erfle H, Reichert J, Lechner J, Beer HD, Pepperkok R, Nickel W (2010) Tec-kinase-mediated phosphorylation of fibroblast growth factor 2 is essential for unconventional secretion. Traffic. 2010 Jun;11(6):813-26