Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und Molekulare Biowissenschaften

Streckfuß-Bömeke, Prof. Dr.

Research Group Leader, Cardiology and Pneumology


  • 2018: Venia legendi (Habilitation), Molecular Medicine, University of Göttingen
  • since 2013: Research group leader at the Institute of Cardiology and Pneumology, University of Göttingen
  • 2006-2013: Post-doctoral researcher at the Institute of Cardiology and Pneumology, University of Göttingen
  • 2006: Post-doctoral researcher at the Institute of Microbiology and Genetics, University of Göttingen
  • 2006: PhD (Biology), Microbiology and Genetics, University of Göttingen, ‘summa cum laude’



Homepage Department/Research Group

https://www.med.uni-wuerzburg.de/pharmatoxi/arbeitsgruppen/arbeitsgruppe-streckfuss-boemeke/



Major Research Interests

Our group utilizes the translational cell model of patient-specific induced pluripotent stem cells (ps-iPSCs) for generation of iPSC-derived pure cardiomyocytes, fibroblasts, neuronal cells, endothelial cells, mesenchymal stem cells as well as human (cardiac) tissue for modeling and analysis of mono-and polygenetic cardiac diseases.
We focus on cardiac diseases such as dilated cardiomyopathy, anthracycline-induced cardiomyopathy, Takotsubo cardiomyopathy, or Arrhythmia-induced Cardiomyopathy, which are suggested to be genetic predisposed.
The aims of all projects are the systematic analysis of the pathogenesis of the cardiac disease mechanisms, the analysis of the immunological response of ps-iPSCs to allogeneic and autologous immune cells, and finally the identification and validation of new molecular targets with potential translational and therapeutic relevance for cardiomyopathies to develop new therapies on a patient-specific level.




Selected publications


  • 1. Beretta M, Santos C, Molenaar C, Hafstad A, Miller C, Revazian A, Betteridge K, Schröder K, Streckfuss-Bömeke K, Doroshow J, Fleck J, Su TP, Belousov V, Parsons M, Shah A (2020). Nox4 regulates InsP3 receptor Ca2+ release to mitochondria to promote cell survival. EMBO J. Oct. 1;39 (19):e103530.

  • 2. Rebs S, Sedaghat-Hamedani F, Kayvanpour E, Meder B, Streckfuss-Bömeke K (2020). Generation of induced pluripotent stem cell lines and CRISPR/Cas9 modified isogenic controls from a DCM patient harboring a RBM20 p.R634W mutation; Stem Cell Res. Jul 2;47:101901.

  • 3. Hübscher D, Rebs S, Haupt L, Borchert T; Guessoum CI, Treu F, Köhne S, Maus A, Hambrecht M, Sossalla S, Dressel R, Uy A; Jakob M, Hasenfuss G, Streckfuss-Bömeke K (2019). A high throughput method as diagnostic tool for HIV detection in patient-specific induced pluripotent stem cells generated by different reprogramming methods. Stem Cells Int. Aug 5;2019:2181437.

  • 4. Streckfuss-Bömeke K, Tiburcy M, Fomin A, Fischer C, Özcelik C, Perrot A, Sossalla S, Haas J, Vidal RO, Khadjeh S, Rebs S, Meder B, Bonn S, Linke WA, Zimmermann WH, Hasenfuß G, Guan K. Severe DCM phenotype of patient harboring RBM20 mutation S635A can be modeled by patient-specific induced pluripotent stem cell-derived cardiomyocytes. J Mol Cell Cardiol. 2017 Dec;113:9-21.

  • 5. Borchert T; Hübscher D; Guessoum CI; Lama T-D; Ghadri JR; Schellinger IN; Tiburcy M; Liaw NY; Yun Li; Haas J; Sossalla S; Huber MA; Cyganek L; Jacobshagen C; Dressel R; Raaz U; Nikolaev VO; Guan K; Thiele H; Meder B; Wollnik B; Zimmermann WH; Lüscher T; Hasenfuß G; Templin C; Streckfuß-Bömeke K (2017). Catecholamine-Dependent β-Adrenergic Signaling in a Pluripotent Stem Cell Model of Takotsubo Cardiomyopathy. JACC, 70(8): 975-91.

  • 6. Streckfuss-Bömeke K, Wolf F, Azizian A, Stauske M, Tiburcy M, Wagner S, Hübscher D, Dressel R, Chen S, Jende J, Wulf G, Lorenz V, Schön MP, Maier LM, Zimmermann WH, Hasenfuss G, Guan K (2013). Comparative study of human induced pluripotent stem cells derived from bone marrow cells, hair keratinocytes and skin fibroblasts. Eur Heart J, 34(33):2618-29.