Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und Molekulare Biowissenschaften

Zimmermann, Wolfram-Hubertus, Prof. Dr.

Professor of Pharmacology


  • 1991 – 1998 Studies of Medicine, University Medical Center Hamburg-Eppendorf
  • 1998 – 2001 Postgraduate Studies of Molecular Biology, Center of Molecular Neurobiology, University Hamburg
  • 1999 – 2003 Resident and Junior Group Leader, Institute of Clinical Pharmacology and Toxicology, University Medical Center Erlangen-Nuremberg
  • 2004 – 2008 Juniorprofessor, Institute of Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf
  • Since 2008 Director, Institute of Pharmacology and Toxicology, University Medical Center Göttingen



Major Research Interests

We focus our research on deciphering the complex cellular processes that underlie organ degeneration, regeneration, and repair. The organ focus of the Zimmermann lab is on heart, brain, and skeletal muscle. We employ advanced human stem cell-based 2D and 3D models to simulate diseases and target therapies to achieve organ level therapeutic outcome. Deep phenotyping at the genome, transcriptome, proteome and functional level as well as integration of obtained data using computational approaches are widely employed. Cell painting and optogenetic tools are developed to visualize and control biological processes. Genome editing is broadly used for target validation and repair. The overarching goal of the Zimmermann lab is to develop and translate advanced medicinal therapy products (ATMPs) into clinical used based on deep systems biology insight.



Homepage Department/Research Group

http://www.pharmacology.med.uni-goettingen.de/



Selected Recent Publications


  • Zafeiriou MP, Bao G, Hudson J, Halder R, Blenkle A, Schreiber MK, Fischer A, Schild D, Zimmermann WH (2020) Developmental GABA polarity switch and neuronal plasticity in Bioengineered Neuronal Organoids. Nat Commun. 11:3791.
  • Schoger E, Carroll KJ, Iyer LM, McAnally JR, Tan W, Liu N, Noack C, Shomroni O, Salinas G, Groß J, Herzog N, Doroudgar S, Bassel-Duby R, Zimmermann WH, Zelarayán LC (2020) CRISPR-Mediated Activation of Endogenous Gene Expression in the Postnatal Heart. Circ Res. 126:6-24.
  • Tiburcy M, Hudson JE, Balfanz P, Schlick S, Meyer T, Chang Liao ML, Levent E, Raad F, Zeidler S, Wingender E, Riegler J, Wang M, Gold JD, Kehat I, Wettwer E, Ravens U, Dierickx P, van Laake LW, Goumans MJ, Khadjeh S, Toischer K, Hasenfuss G, Couture LA, Unger A, Linke WA, Araki T, Neel B, Keller G, Gepstein L, Wu JC, Zimmermann WH (2017) Defined Engineered Human Myocardium with Advanced Maturation for Applications in Heart Failure Modelling and Repair. Circulation 135:1832-1847.
  • Liao MLC, de Boer TP, Mutoh H, Raad N, Richter C, Wagner E, Downie BR, Unsöld B, Arooj I, Streckfuss-Bömeke K, Döker S, Luther S, Guan K, Wagner S, Lehnart SE, Maier LS, Stühmer W, Wettwer E, van Veen T, Morlock MM, Knöpfel T, Zimmermann WH (2015) Sensing Cardiac Electrical Activity with a Cardiomyocyte Targeted Optogenetic Voltage Indicator. Circ Res 117:401-412.
  • Didié M, Christalla P, Rubart M, Muppala V, Döker S, Unsöld B, El-Armouche A, Rau T, Eschenhagen T, Schwoerer AP, Ehmke H, Schumacher U, Fuchs S, Lange C, Becker A, Tao W, Scherschel JA, Soonpaa MH, Yang T, Lin Q, Zenke M, Han DW, Schöler HR, Rudolph C, Steinemann D, Schlegelberger B, Kattman S, Witty A, Keller G, Field LJ, Zimmermann WH (2013) Parthenogenetic Stem Cells for Tissue Engineered Heart Repair. J Clin Invest 123:1285-1298.