Chairini Cássia Thomé

EDUCATION

College / University

Federal University of Rio Grande do Sul (02/2011 – 12/2016 and 03/2017 – 02/2019)
Eberhard Karls Universität Tübingen (10/2015 – 08/2016)

Highest Degree

Master of Science

Major Subjects

Biochemistry

Country

Brazil

Lab Experience

Culture of tumor cell lineages and bacteria, in vitro pharmacological screening, protein-quantification assays, cell-viability assays, FACS, virus titration, Western Blot, ELISA, animal handling, in vivo drug administration, animal perfusion, glutamate-uptake assay, PCR, analysis of gene-expression data.

Projects / Research

03/2017 – 02/2019: “Evaluation of the prognostic potential of metabotropic glutamate receptors in glioblastoma”, supervisor: Prof. Dr. Diogo Losch de Oliveira, Department of Biochemistry, Institute of Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
04/2016 – 07/2016: “Investigation of the antiviral capacity of MEK-Inhibitors against Influenza A Virus”, supervisor: Prof. Dr. rer. nat. Oliver Planz, Department of Immunology, Eberhard Karls Universität Tübingen, Tübingen, Germany.
08/2011 – 06/2015: “Behavior- and neurochemical- evaluation in convulsion’s models during development”, “Comparison of glutamatergic system parameters between early and late cultures of C6 cells”, and “Evaluation of antitumoral effect of imidazolium ionic liquids in glioblastoma cell lineages” supervisor: Prof. Dr. Diogo Losch de Oliveira, Department of Biochemistry, Institute of Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.

Scholarships / Awards

2019 – 2020:	Stipend by the International Max Planck Research School
2017 – 2019:	Graduate Scholarship, National Council for Scientific and Technological Development (CNPq), Federal University of Rio Grande do Sul, Brazil
2018:	DAAD Scholarship, Winter Course for Foreign University Students and Graduates, Germany
2015 – 2016:	Science without Borders Scholarship, Brazilian Coordination for Improvement of Higher Education Personnel (CAPES), exchange studies at Eberhard Karls Universität Tübingen, Germany
2011 – 2015:	Undergraduate Research Scholarship, CNPq, Federal University of Rio Grande do Sul, Brazil

SCIENTIFIC INTERESTS AND GOALS

My main scientific interest lies in the relationship between the fields of epigenetics and molecular oncology. It is well known that cancer is a disease caused by genetic alterations leading to abnormal expression of genes. However, some alterations in gene expression cannot be explained exclusively by changes in the genome of tumor cells. This situation opens space to epigenetics, which can help to explain the transcriptomic alterations that are not caused by mutations. Thus, I am interested in studying how epigenetic mechanisms regulate gene expression in physiological and pathological conditions, such as cancer. In the future, my goal is to investigate the role of these regulatory mechanisms in cancer, more specifically, their involvement in tumorigenesis, resistance to therapy and tumor progression.