Dr. Oliver Barnstedt
Group Leader, Multiscale Circuit Analysis, MBExC and ENI, University Medical Center Göttingen
- 2009 – 2012: BSc in Neuroscience and Cognitive Psychology from Jacobs University Bremen, Germany
- 2012 – 2013 : MSc in Neuroscience from University of Oxford, United Kingdom
- 2013 – 2017: PhD student with Prof Scott Waddell at Centre for Neural Circuits and Behaviour, University of Oxford, United Kingdom
- 2018: Doctor of Philosophy from University of Oxford, United Kingdom
- 2017 – 2022 : Postdoctoral researcher, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany
- 2022 – 2024 : Postdoctoral researcher, Leibniz Institute for Neurobiology (LIN) Magdeburg, Germany
- 2024: Junior Research Group Leader, Otto-von-Guericke University Magdeburg, Germany
- since 2024: Group Leader, Multiscale Circuit Analysis, MBExC and ENI, University Medical Center Göttingen, Germany
- Barnstedt, O, Mocellin P, Remy S. 2024. A hippocampus-accumbens code guides goal-directed appetitive behavior. Nature Communications, 15: 3196
- Mocellin P, Barnstedt O, Luxem K, Kaneko H, Karpova A, Henschke J, Dalügge D, Fuhrmann F, Pakan J, Kreutz MR, Mikulovic S, Remy S. 2024. A septal-ventral tegmental area circuit drives exploratory behavior. Neuron, 112 (6): 1020-1032.E7
- Felsenberg J, Barnstedt O, Cognigni P, Lin S, Waddell S. 2017. Re-evaluation of learned information in Drosophila. Nature, 544(7649): 240-244
- Žurauskas M, Barnstedt O, Frade-Rodriguez M, Waddell S, Booth MJ. 2017. Rapid adaptive remote focusing microscope for sensing of volumetric neural activity. Biomedical optics express, 8(10): 4369-4379
- Barnstedt O, Owald D, Felsenberg J, Brain R, Moszynski J, Talbot CB, Perrat P, Waddell S. 2016. Memory-Relevant Mushroom Body Output Synapses Are Cholinergic. Neuron, 89(6): 1237–1247
- Barnstedt OBarnstedt O, Keating P, Weissenberger Y, King AJ, Dahmen JC. 2015. Functional microarchitecture of the mouse dorsal inferior colliculus revealed through in vivo two-photon calcium imaging. Journal of Neuroscience 35 (31), 10927-10939
Major Research Interests
Our ability to perceive and interact with the world around us relies on finely tuned interactions of neural populations across the brain. To understand the functional mechanisms of these interactions, we need to record and manipulate neural activity across multiple scales: from subcellular structures to individual neurons and circuits to networks, which give rise to an organism’s behaviour. Our group is using advanced optical tools such as multicolour in vivo two-photon calcium and closed-loop optogenetics alongside high-resolution tracking of behaving mice and computational analysis to bridge this gap and understand how neural circuits give rise to perception, memory and action.
The focus of our work lies in understanding how the hippocampal memory system integrates sensory and motor information to form long-lasting memories and, importantly, how precisely these memories are influencing behavioural action. For this, we are specifically investigating the neural interactions between hippocampus and hypothalamus, as well as the ventral striatum. We hope that our findings on the circuit mechanisms of memory processing will enable a better understanding of related diseases such as Alzheimer’s and offer potential therapeutic approaches.
Ultimately, we are hoping to identify and describe a complete neural circuit from sensory input to its integration with previous experience to motor action.
Homepage Department/Research Group
https://www.barnstedtlab.com
https://eni-g.de/groups/multiscale-circuit-analysis
Google Scholar:
https://scholar.google.com/citations?user=YArxXYgAAAAJ&hl=en
Selected Recent Publications