Stadelmann-Nessler, Christine, Prof. Dr. med.

Professor of Neuropathology

Dr. med. univ. (M.D., University of Vienna, Austria)
Dr. med. (Humboldt-University Berlin, Germany)
Post-doctoral studies with Hans Lassmann, Brain Research Institute, Vienna, and Wolfgang Brück, Berlin and Göttingen
Since 2011: W3 professor of neuropathology, University Medical Center Göttingen

Major Research Interests

Pathogenesis of myelin and oligodendrocyte damage in demyelinating diseases, e.g., multiple sclerosis, acute disseminated encephalomyelitis, a.o.
Neuroaxonal damage in demyelinating diseases
Remyelination

Homepage Department/Research Group
http://www.neuropathologie.med.uni-goettingen.de/deutsch/forschung/ag-c.stadelmann.htm

Selected publications

Bergner CG, van der Meer F, Winkler W, Wrzos C, Türkmen M, Valizada E, Fitzner D, Hametner S, Hartmann A, Pfeifenbring S, Stoltenburg-Didinger G, Brück W, Nessler S, Stadelmann C. Microglia damage precedes major myelin destruction in X-linked adrenoleukodystrophy and metachromatic leukodystrophy. Glia 2019; Feb 11. doi: 10.1002/glia.23598
Masuda T*, Sankowski R*, Staszewski O*, Böttcher C, Amann L, Sagar, Scheiwe C, Nessler S, Kunz P, van Loo G, Coenen VA, Reinacher PC, Michel A, Sure U, Gold R, Grün D, Priller J, Stadelmann C., Prinz M. Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution. Nature 2019; 566(7744):388-392.
Töpperwien M, van der Meer F, Stadelmann C., Salditt T. Three-dimensional virtual histology of human cerebellum by X-ray phase-contrast tomography. Proc Natl Acad Sci U S A 2018; Jul 3;115(27):6940-6945. doi: 10.1073/pnas.1801678115.
Fard MK*, van der Meer F*, Sánchez P, Cantuti-Castelvetri L, Mandad S, Jäkel S, Fornasiero EF, Schmitt S, Ehrlich M, Starost L, Kuhlmann T, Sergiou C, Schultz V, Wrzos C, Brück W, Urlaub H, Dimou L, Stadelmann C#, Simons M#. BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions. Sci Transl Med. 2017 Dec 6;9(419). doi: 10.1126/scitranslmed.aam7816. *co-first; # co-last and corresponding
Lagumersindez-Denis N*, Wrzos C*, Mack M*, Winkler A, van der Meer F, Reinert MC, Hollasch H, Flach A, Bruhl H, Cullen E, Schlumbohm C, Fuchs E, Linington C, Barrantes-Freer A, Metz I, Wegner C, Liebetanz D, Prinz M, Brück W, Stadelmann C#, and Nessler S#. Differential contribution of immune effector mechanisms to cortical demyelination in multiple sclerosis. Acta Neuropathol 2017; 134(1):15-34. #corresponding authors
Singh S*, Dallenga T*, Winkler A, Roemer S, Maruschak B, Siebert H, Brück W#, Stadelmann C#. Relationship of acute axonal damage, Wallerian degeneration and clinical disability in multiple sclerosis. J Neuroinflammation 2017; Mar 17;14(1):57. doi: 10.1186/s12974-017-0831-8; # co-last
Barrantes-Freer A, Engel AS, Rodríguez-Villagra OA, Winkler A, Bergmann M, Mawrin C, Kuempfel T, Pellkofer H, Metz I, Bleckmann A, Hernández-Durán S, Schippling S, Rushing EJ, Frank S, Glatzel M, Matschke J, Hartmann C, Reifenberger G, Müller W, Schildhaus HU, Brück W, Stadelmann C. Diagnostic Red Flags: Steroid-Treated Malignant CNS Lymphoma Mimicking Autoimmune Inflammatory Demyelination. Brain Pathol 2017; Feb 18. doi: 10.1111/bpa.12496.
Albert M*, Barrantes-Freer A*, Lohrberg M, Antel JP, Prineas JW, Palkovits M, Wolff JR, Brück W, Stadelmann C. Synaptic pathology in the cerebellar dentate nucleus in chronic multiple sclerosis. Brain Pathol 2016; Oct 5. doi: 10.1111/bpa.12450.
Rodriguez, E. G.*, C. Wegner*, M. Kreutzfeldt, K. Neid, D. R. Thal, T. Jurgens, W. Brück, C. Stadelmann#, D. Merkler#. Oligodendroglia in cortical multiple sclerosis lesions decrease with disease progression, but regenerate after repeated experimental demyelination. Acta Neuropathol 2014; 128:231-246. # co-last
Wrzos, C., A. Winkler, I. Metz, D. M. Kayser, D. R. Thal, C. Wegner, W. Brück, S. Nessler, J. L. Bennett, C. Stadelmann. Early loss of oligodendrocytes in human and experimental neuromyelitis optica lesions. Acta Neuropathol 2014; 127:523-538.