Brück, Wolfgang, Prof. Dr.

Professor of Neuropathology

1986 MD Johannes Gutenberg University in Mainz, 1994 national boards in neuropathology
1996-2002 Associate professorships for neuropathology at the University of Göttingen and the Charité in Berlin
Since 2002 full professor and director of the Department of Neuropathology, University of Göttingen

Major Research Interests

- Immunopathology of multiple sclerosis
- Brain-specific mechanisms of immune response in multiple sclerosis
- Axonal damage in inflammatory demyelination and mechanisms of remyelination
- Mechanisms and consequences of microglial activation

Homepage Department/ Research Group

https://neuropathologie.umg.eu/forschung/arbeitsgruppen-labore/ag-wolfgang-brueck/

Selected Recent Publications

Lagumersindez-Denis N, Wrzos C, Mack M, Winkler A, van der Meer F, Reinert MC, Hollasch H, Flach A, Brühl H, Cullen E, Schlumbohm C, Fuchs E, Linington C, Barrantes-Freer A, Metz I, Wegner C, Liebetanz D, Prinz M, Brück W, Stadelmann C, Nessler S (2017) Differential contribution of immune effector mechanisms to cortical demyelination in multiple sclerosis. Acta Neuropathol, 134: 15-34
Fard MK, van der Meer F, Sánchez P, Cantuti-Castelvetri L, Mandad S, Jäkel S, Fornasiero EF, Schmitt S, Ehrlich M, Starost L, Kuhlmann T, Sergiou C, Schultz V, Wrzos C, Brück W, Urlaub H, Dimou L, Stadelmann C, Simons M (2017) BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions. Sci Transl Med, 2017 Dec 6;9(419)
Romanelli E, Merkler D, Mezydlo A, Weil MT, Weber MS, Nikić I, Potz S, Meinl E, Matznick FE, Kreutzfeldt M, Ghanem A, Conzelmann KK, Metz I, Brück W, Routh M, Simons M, Bishop D, Misgeld T, Kerschensteiner M (2016) Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model. Nat Commun., 2016 Nov 16;7:13275
Kinzel S, Lehmann-Horn K, Torke S, Häusler D, Winkler A, Stadelmann C, Payne N, Feldmann L, Saiz A, Reindl M, Lalive PH, Bernard CC, Brück W, Weber MS (2016) Myelin-reactive antibodies initiate T cell-mediated CNS autoimmune disease by opsonization of endogenous antigen. Acta Neuropathol, 132: 43-58
Jürgens T, Jafari M, Kreutzfeldt M, Bahn E, Brück W, Kerschensteiner M, Merkler D (2016) Reconstruction of single cortical projection neurons reveals primary spine loss in multiple sclerosis. Brain, 139: 39-46
Pfeifenbring S, Bunyan RF, Metz I, Röver C, Huppke P, Gärtner J, Lucchinetti CF, Brück W (2015) Extensive acute axonal damage in pediatric multiple sclerosis lesions. Ann. Neurol., 77: 655-667
Metz I, Weigand SD, Popescu BF, Frischer JM, Parisi JE, Guo Y, Lassmann H, Brück W, Lucchinetti CF (2014) Pathologic heterogeneity persists in early active multiple sclerosis lesions. Ann. Neurol., 75: 728-738
Brück W, Gold R, Lund BT, Oreja-Guevara C, Prat A, Spencer CM, Steinman L, Tintoré M, Vollmer TL, Weber MS, Weiner LP, Ziemssen T, Zamvil SS (2013) Therapeutic decisions in multiple sclerosis: moving beyond efficacy. JAMA Neurol., 70: 1315-1324
Singh S, Metz I, Amor S, van der Valk P, Stadelmann C, Brück W (2013) Microglial nodules in early multiple sclerosis white matter are associated with degenerating axons. Acta Neuropathol., 125: 595-608
Brück W, Pförtner R, Pham T, Zhang J, Hayardeny L, Piryatinsky V, Hanisch UK, Regen T, van Rossum D, Brakelmann L, Hagemeier K, Kuhlmann T, Stadelmann C, John GR, Kramann N, Wegner C (2012) Reduced astrocytic NF-?B activation by laquinimod protects from cuprizone-induced demyelination. Acta Neuropathol., 124:411-424
Brück W, Popescu B, Lucchinetti CF, Markovic-Plese S, Gold R, Thal DR, Metz I (2012) Neuromyelitis optica lesions may inform multiple sclerosis heterogeneity debate. Ann. Neurol., 72:385-394
Metz I, Radue EW, Oterino A, Kümpfel T, Wiendl H, Schippling S, Kuhle J, Sahraian MA, Gray F, Jakl V, Häusler D, Brück W (2012) Pathology of immune reconstitution inflammatory syndrome in multiple sclerosis with natalizumab-associated progressive multifocal leukoencephalopathy. Acta Neuropathol., 123:235-245