Göttingen Graduate Center for Neurosciences, Biophysics, and Molecular Biosciences

Singh, Shiv K., Ph.D.


  • 2006-2010 Ph.D. in Molecular Medicine from Philipps-University of Marburg, Germany
  • 2011-2013 Postdoctoral Fellow at Philipps-University of Marburg, Germany
  • 2014-2016 Postdoctoral Fellow at Barrow Neurological Institute, Phoenix, AZ, USA
  • 2016-2018 Junior Group Leader, Principal Investigator at the Department of Gastroenterology and Gastrointestinal Oncology, University Medical Center of Goettingen, Germany
  • Since 2018 Max-Eder Group Leader, Principal Investigator at the Department of Gastroenterology and Gastrointestinal Oncology, University Medical Center of Goettingen, Germany



Major Research Interests


  • Inflammatory microenvironment in cancer progression and chemoresistance
  • Lineage-specific transcriptional reprogramming in cancer cell plasticity
  • Transcription factor networks and chromatin regulation in tumor progression



Homepage Department/Research Group

http://gastroenterologie-goettingen.de/index.php/klinische-studien



Selected Recent Publications


  • Singh SK, Fiorelli R, Kupp R, Rajan S, Szeto E, Lo Cascio C, Maire CL, Sun Y, Alberta JA, Eschbacher JM, Ligon KL, Berens ME, Sanai N, Mehta S (2016). Post-translational modification of Olig2 regulates glioma invasion through TGF-β2 mediated signaling pathway.
    Cell Reports; 16:950-66.

  • Singh SK, Chen N, Hessmann E Siveke J, Lahmann M, Singh G, Voelker N, Vogt S, Esposito I, Schmidt A, Brendel C, Stiewe T, Gaedcke J, Mernberger M, Crawford HC, Bamlet WR, Zhang JS, Li XK, Smyrk TC, Billadeau DD, Hebrok M, Neesse A, Koenig A, Ellenrieder V (2015). Antithetical NFATc1-Sox2 and p53-miR-200 signalling networks governs pancreatic cancer cell plasticity and tumour progression.
    EMBO J; 34:517-30.

  • Baumgart S, Chen N, Siveke J, Koenig A, Zhang J, Singh SK, Wolf E, Bartkuhn M, Esposito I, Heßmann E, Reinecke J, Nikorowitsch J, Brunner M, Singh G, Fernandez-Zapico ME, Smyrk T, Bamlet WR, Eilers M, Neesse A, Gress TM, Billadeau DD, Tuveson D, Urrutia R, Ellenrieder V (2014). A Nuclear NFATc1-STAT3 Transcription Pathway Promotes Pancreatitis-Associated Cancer initiation by KrasG12D.
    Cancer Discovery; 4:688-701.

  • Baumgart S, Glesel E, Singh G, Chen NM, Reutlinger K, Zhang J, Billadeau DD, Fernandez-Zapico ME, Gress TM,
    Singh SK*, Ellenrieder V* (2012). p15INK4b promoter restricted heterochromatin formation links NFATc2 repressor function with growth promotion in pancreatic cancer.
    Gastroenterology; 142:388-98. (*Equally contributed)

  • Singh SK and Ellenrieder V (2013). Senescence in Pancreatic Cancer: from signalling to chromatin remodelling and epigenetics. GUT; 1364-72.

  • Singh SK, Baumgart S, Singh G, König A, Reutlinger K, Hofbauer LC, Gress TM, Fernandez-Zapico ME, Urrutia R, Ellenrieder V (2011). Disrupting a nuclear NFATc2 protein stabilization loop confers breast and pancreatic cancer growth suppression by zoledronic acid. J Biol Chem; 286:28761-71.

  • Singh G*, Singh SK*, König A, Reutlinger K, Eilers M, Gress TM, Fernandez-zapico ME, Ellenrieder V (2010).. Sequential activation of NFAT and c-Myc transcription factors mediates the TGF-ß switch from a suppressor to a promoter of cancer cell proliferation. J Biol Chem; 285:27241-50. (*Equally contributed)