Carlos Eduardo da Cunha

EDUCATION

College / University

Federal University of São Paulo – Medical College, São Paulo

Highest Degree

Bachelor of Science

Major Subjects

Biochemistry, Biophysics and Bioinformatics

Country

Brazil

Lab Experience

Techniques in biochemistry (HPLC, LCMS-ES, chromatography), biophysics (FRET peptides, protein crystallization), bioinformatics (protein modeling, molecular modeling, protein interaction) and organic chemistry (compound modifications, peptide synthesis)

Projects / Research

01/2007 – 12/2007: Biochemical characterization of oligopeptidase A of E.coli and an approach on its predicted structure when comparing to homologues proteins
06/2006 – 12/2006: Biochemical characterization of dipeptidylcarboxypeptidase from E.coli and a structural study on its inhibition mechanism
07/2005 – 05/2006: Characterization of a serine-thiol protease from Paracoccidioides brasiliensis and its organic derivative inhibitor

Publications

Matsuo AL, Carmona AK, Silva LS, Cunha CE, Nakayasu ES, Almeida IC, Juliano MA, Puccia R (2007) C-Npys (S-3-nitro-2-pyridinesulfenyl) and peptide derivatives can inhibit a serine-thiol proteinase activity from Paracoccidioides brasiliensis. Biochem Biophys Res Commun 355(4):1000-5

Scholarships / Awards

2008 – 2009:	Stipend by the International Max Planck Research School
2005 – 2007:	Scholarship from the Brazil National Council of Scientific and Technological Development

SCIENTIFIC INTERESTS AND GOALS

I am fascinated with bioinformatics and structural biology. The way all those small particles work among themselves in a perfect synchrony amazes me, and having the opportunity to understand how all this work and its implication on drug design is what drives me into this field.