Kehlenbach, Ralph, Prof. Dr.

Professor, Department of Molecular Biology

Diploma in biology, University of Bonn, 1992
Dr. rer. nat., University of Heidelberg, 1995
Postdoctoral fellow, The Scripps Research Institute, USA, 1996-2000
Group leader University of Heidelberg, 2000-2004
Group leader University of Göttingen, since 2005
Habilitation in Biochemistry and Molecular Biology, 2007

Major Research Interests
Transport of macromolecules between the nucleus and the cytoplasm occurs through nuclear pore complexes (NPCs), large supramolecular structures that are embedded between the outer and the inner nuclear membrane. Whereas small molecules (< 40 kDa) may passively diffuse through the NPC, nuclear transport of larger proteins or nucleic acids is an energy-dependent, signal-mediated process.
We are characterizing the function of several nuclear transport receptors with a particular focus on CRM1, the major export receptor for transport of proteins as well as different RNA species out of the nucleus. Furthermore, we are analyzing the transport mechanisms of proteins that are targeted to the inner nuclear membrane. Finally, we are interested in the role of individual nucleoporins in nuclear transport of soluble and membrane-bound proteins. For our analyses, we use a large variety of structural, biochemical and cell biological approaches.

Homepage Department/Research Group
https://biochemie.uni-goettingen.de/index.php/nuclear-transport-ag-kehlenbach-3/

ORCID: 0000-0003-4920-9916