Veranstaltung
Translational Hearing Research – Examples on the Journey from Bench to Bedside
| Titel der Veranstaltung | Translational Hearing Research – Examples on the Journey from Bench to Bedside |
| Reihe | EKFZ Lecture |
| Veranstalter | Else Kröner Fresenius Center for Optogenetic Therapies |
| Referent/in | Prof. Dr. Christoph Arnoldner & Dr. Erdem Yildiz |
| Einrichtung Referent/in | Medical University of Vienna |
| Veranstaltungsart | Vortrag |
| Kategorie | Forschung |
| Anmeldung erforderlich | Nein |
| Beschreibung | This lecture presents a translational research program that spans in vitro experiments, rodent models, and large-animal studies, culminating in early clinical applications for sensorineural hearing loss of diverse origins. Candidate drug formulations – such as the promising pyridoindole compound AC102 – are initially screened in ex-vivo cochlear explant cultures and subsequently tested in a gerbil model of cochlear-implantation trauma to evaluate functional recovery. Compounds showing robust effects are then advanced to a porcine model that closely resembles the human inner ear in size and surgical anatomy, enabling detailed analyses of pathophysiology and intracochlear pharmacokinetics. We also investigate cochlear implantation – the world’s most widely used neuroprosthetic device – with a focus on optimizing atraumatic electrode insertion and comparing different strategies for local drug delivery. In parallel, we explore a “liquid biopsy” approach by analyzing perilymph biomarkers that may provide insights into the mechanisms underlying hearing loss. The translational pathway extends into early clinical practice, including first experiences with local intracochlear drug injection and robot-assisted, low-trauma cochlear implantation. Finally, we discuss gene-based interventions, highlighting ongoing industry-sponsored clinical trials for OTOF-related congenital deafness in children, supported by complementary porcine models for future gene-therapy development. Together, these studies outline a continuous pipeline from basic discovery to patient-ready treatments. |
| Zeit | Beginn: 07.01.2026, 16:00 Uhr Ende: 07.01.2026 , 17:00 Uhr |
| Ort |
Universitätsmedizin Göttingen (2) (Von-Siebold-Straße 5) Lecture Hall 04 |
| Kontakt |
Dr. Marie Freier ekfz@med.uni-goettingen.de |
| Externer Link | https://ekfz.uni-goettingen.de/ |
| Dateianhang | Flyer_EKFZ Lecture_Christoph Arnoldner & Erdem... |