Research Area

Functional nucleic acids in organic and biomolecular chemistry for labeling, detection and visualization of biomolecules

• RNA labeling with deoxyribozymes using DNA-catalyzed ligation chemistry


• Synthesis of fluorescent labeling reagents, e.g. dye-labeled nucleoside triphosphates


• Synthesis of paramagnetic nucleoside building blocks for EPR spectroscopy


• In-vitro selection of fluorogenic RNA and DNA aptamers


• Detection of natural modified nucleosides by fluorogenic bioorthogonal labeling


• In-vitro selection of modification-specific deoxyribozymes


• Structural and mechanistic analysis of nucleic acid catalysis