Shreshth Shekhar

EDUCATION

College / University

Indian Institute of Science Education and Research, Thiruvananthapuram

Highest Degree

BS-MS (Integrated Master)

Major Subjects

Biological Sciences, Neurobiology, Clinical Neurosciences

Country

India

Lab Experience

Stereotactic Surgeries, Perfusion, Sectioning using vibratome, Immunohistochemistry, Immunofluorescence, Rodent behavioural analysis, mouse handling and administration of IP injections, Western Blots, SDS PAGE, Pharmacokinetic/Pharmacodynamic analysis using LC-HRMS, fMRI data analysis using FSL, Python, MATLAB and R programming

Projects / Research

08/2022-05/2023: In vivo efficacy of PD180970 in ameliorating Parkinson’s disease pathophysiology in an alpha synuclein based murine model (Master's thesis). Thakur Neurodegeneration Lab, Indian Institute of Science Education and Research, Thiruvananthapuram
05/2022- 07/2022 : Global Resting State Functional Connectivity and it's Clinical Correlates in Drug Naiive Schizophrenia (summer internship). Transcranial Magnetic Stimulation Lab, National Institute of Mental Health and Neurosciences
01/2022- 04/2022 : Qualitative and Quantitative assessment of Sleep in Drosophila under the effect of Caffeine using Drosophila Activity Monitor data (Minor Dissertation in Data Sciences). Chronobiology Lab, Indian Institute of Science Education and Research, Thiruvananthapuram

Scholarships / Awards

2023 – 2024:

Stipend by the International Max Planck Research School

SCIENTIFIC INTERESTS AND GOALS

I find my research interests akin to a neuron with the soma comprising of core neurobiological concepts with its vast dendritic arborizations in psychiatry, psychology and allied behavioural sciences. I'm interested in identifying the molecular mechanisms underlying the characteristic and pathological behavioural manifestations of neuropsychiatric disorders such as Schizophrenia, in order to strengthen our understanding of the fundamental neurobiology underlying these disorders and thereby develop innovative therapeutic interventions which are grounded in core neurobiological realities. I believe the best way to tackle this question is through a translational approach, by bridging the gap between patient findings and dissecting and teasing apart the molecular mechanisms of these findings in animal models