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Towards retraining dysfunctional brain circuits in neurodegenerative movement disorders

Title of the event Towards retraining dysfunctional brain circuits in neurodegenerative movement disorders
Series ENI Lecture (zoom)
Organizer European Neuroscience Institute
Speaker Sonja Blumenstock
Speaker institution University of California, San Diego
Type of event Vortrag
Category Forschung
Registration required Nein
Details Neurodegenerative diseases disturb all of these functions and dementia is arguably the heaviest medical and personal burden of ageing societies. Movement disorders such as Parkinson’s Disease (PD) and Huntington’s Disease (HD) are further characterized by involuntary motor dysfunction, which are progressively debilitating. Selective degeneration of the corticostriatal-basal-ganglia-thalamocortical loop is prominent in PD and HD and while most research and treatment efforts have been directed towards the basal ganglia, the accessible cortex, located on the surface of the brain has received much less attention.
The underlying mechanisms for PD and HD are far from being well understood. An intersection of molecular changes, structural degeneration and imbalance of communication between individual neurons and across brain regions creates a multilevel complexity, complicating research. Nevertheless, recent years have brought exciting new technologies that enable both systemic gene delivery as well as measurement and manipulation of brain components at unprecedented precision and scale, making the vision of a comprehensive understanding more realistic than ever before.
Date Start: 04.01.2022, 16:00 Uhr
Ende: 04.01.2022 , 16:45 Uhr
Location https://uni-goettingen.zoom.us/j/92910021738?pwd=MnREOWgrMUUwakExcEdOTVEyZ2Yydz09
Meeting-ID: 929 1002 1738 Kenncode: 912155
Contact 0551 39 61300
eni@gwdg.de
External link https://uni-goettingen.zoom.us/j/91390811763?pw...